Endocrine Abstracts

Low thyroid function in pregnancy is associated with adverse obstetric outcomes but it is unclear whether screening and initiation of levothyroxine during pregnancy is beneficial. The Controlled Antenatal Thyroid Study (CATS) was a randomised controlled trial which screened women for low thyroid function (subclinical hypothyroidism and isolated hypothyroxinemia) between 11 and 16 weeks gestation. CATS provides data on obstetric outcomes and offspring neurological development. ...

Objectives: Hyperthyroidism is associated with a high basal metabolic rate and weight loss is a common symptom. However, it has been observed, that once patients are treated, they gain back the lost weight and may also put on more. Given that weight gain is a health factor, there’s interest in studying the effect that the thyroid levels have on weight gain and potential harmful health consequences.Methods: 79 patients (58 female) with hyperthyroidis...

Gonadal dysgenesis with DAX1 duplication as the cause of XY disorder of sexual development is a rare condition. Duplication of this causes male to female sex reversal while mutation or deletion can cause adrenal hypoplasia congenita with hypogonadotropic hypogonadism. We present a case of 37-year-old lady who was referred to endocrine clinic with ongoing symptoms of fatigue. She was diagnosed with 46 XY gonadal dysgenesis when she presented with groin swelling at the ...

Iodothyronamines are endogenous trace amines which are putative products of thyroid hormone decarboxylation by Aromatic Amino acid Decarboxylase (AADC). 3-Iodothyronamine (T1AM) has been shown to have profound effects on rodents in vivo, including reductions in body temperature, blood pressure and cardiac output, alongside a switch from carbohydrate to fat utilisation. It is possible that T1AM induces some of these effec...

On behalf of the Combined immunosuppression & radiotherapy in thyroid eye disease (CIRTED) InvestigatorsBackground: Thyroid eye disease is an inflammatory orbital condition which causes visual dysfunction and psychological morbidity. Current evidence is conflicting on the benefit of radiotherapy and antiproliferative immunosuppression in addition to systemic corticosteroid treatment. In particular, little is known about clinical outcomes mor...

On behalf of the Combined immunosuppression & radiotherapy in thyroid eye disease (CIRTED) InvestigatorsBackground: Thyroid eye disease is an inflammatory orbital condition which causes visual dysfunction and psychological morbidity. Current evidence is conflicting on the benefit of radiotherapy and antiproliferative immunosuppression in addition to systemic corticosteroid treatment. In particular, little is known about clinical outcomes mor...

Background: Radioiodine therapy (I-131) is commonly prescribed for benign thyroid disease in keeping with recommended guidelines.Aims: To determine the effectiveness of I-131 in treating benign thyroid disease and the rates of hypothyroidism following treatment and by diagnosis.Methods: We identified 100 patients who received radioiodine therapy between November 2013 and June 2015 from a database held in the Medical Physics Departm...

Introduction: There has been a substantial increase in our knowledge of the genetic architecture of thyroid function, with numerous variants associated with TSH and/or FT4 levels. However, our knowledge of the genetic variants associated with thyroid disease is more limited.Methods: Data was obtained from the Neale laboratory† which provided a case-control study to identify single nucleotide polymorphisms associated with a diagnosis of hypothyroidi...

Context: Thyroid eye disease is disabling and disfiguring and has a substantial negative impact on quality of life. Medical therapies to reduce inflammation are widely used, but there is limited data from clinical trials beyond 6 months of follow-up. Methods: 3 year follow-up of a subset of the CIRTED trial (n = 68) which randomized patients to receive high-dose oral steroid with azathioprine/placebo and radiotherapy/sham radiotherapy. We compar...

Objective: Thyroid hormones are essential for maintaining metabolic balance and particularly influence lipid synthesis and degradation. Metabolomics and in-depth lipid profiling may enable us to assess for differential effects of thyroid hormones and provide insight into tissue thyroid status, that cannot be captured by levels of serum free thyroid hormones alone.Methods: 4,347 children from the Avon Longitudinal Study of Parents and Children who had thy...